HappyAir Digital Health Ecosystem: an integrated care management solution focused on respiratory conditions, for healthcare practitioners, patients and family-caregivers. (by Lovexair Foundation)

HappyAir is a hybrid digital health platform (web + mobile app) integrating:

• Patient self-management tools. Digital tools self-care and symptom monitoring. (e.g. Check@ir).
• Remote clinical monitoring.
• Social community support.
• Tele-coaching by respiratory specialists.
• Data analytics dashboard for HCPs.

Description

A validated ecosystem for chronic & rare respiratory disease management amongst these: COPD, asthma, bronchiectasis, chronic cough, pulmonay fibrosis, pulmonary hipertension, LONG-COVID, Alpha-1-Antitrypsin deficiency, cystic fibrosis… that combines:

• Clinical protocols: Digitalized monitoring for pulmonary rehab, symptom tracking, medication adherence, physical activity, respiratory physiotherapy, anxiety, comobidity key indicators, lifestyle.
• Education: Educational contents about respiratory diseases.
• Social health: Peer support communities and expert-led education.
• AI-driven insights: Predictive analytics for exacerbation risk and personalized care plans.
• Hybrid care model: Blends in-personal assessments (e.g. spirometry via Check@ir events) with virtual coachin when these activities can be carried out.

How it works

The HappyAir Digital Ecosystem can be implemented and used through a step-by-step, hybrid digital-physical integration model, designed for scalability across different healthcare systems and patient populations.

Implementation Steps

Patients Onboarding:

• Patients are identified via:
  • Clinical referrals from pulmonologists or primary care providers.
  • Screening using Check@ir tool.
• Onboarding includes consent, language preference setup, and initial health assessment.

Personalized Digital Care Plan Activation: Once enrolled, patients receive a tailored care plan including:

• Daily symptom tracking.
• Medication reminders and adherence monitoring.
• Personalized exercise programs (digital pulmonary rehabilitation).
• Educational content delivered via app (videos, infographics).

Remote Monitoring & AI-Driven Insights:

• Patients use the mobile app to log data (symptoms, medication use, physical activity, mood, adverse events, oxygen saturation…).
• Integration with Bluetooth spirometers and wearables enables automatic physiological data collection.
• AI algorithms analyze trend to predict exacerbation risk and alert clinicians.

Tele-Coaching and Clinical Intervention:

• Respiratory physiotherapists conduct scheduled video coaching sessions.
• High-risk patients flagged by AI are priritized for early intervention.

Community engagement:

• Join disease-specific groups (e.g. COPD, asthma… by language).
• Whatsapp Communities.
• Participate in R&D studies.
• Test devices or digital health IoT.

Clinician Access & Workflow Integration:

• Healthcare providers access a real-time dashboard showing patient metricts.
• Data is viewable within hospital EHRs via HL7/FHIR-compliant APIs (in pilot phase).
• Alerts help to prioritize follow-ups and reduce preventable.

Hybrid Care Events: Periodic in-person assessments include spirometry and clinical exams, complementing virtual care.

Development

Current version of HappyAir Ecosystem has been developed from 2022 onwards, by Lovexair team supported by Live Breathe Smile lda SME with the collaboration of our Advisory board composed of Health Care Professionals (Pneumologists, Allergologists, Primary Care Doctors, Physiotherapists, Researchers) and Patients/Caregivers, organizations and individuals with differentes diseases (e.g. Bronchiectasis, Alpha-1, Cystic Fibrosis, Pulmonary Hypertension).

Scalable deployment:

• Implemented in public health systems, rehab centers and pharmacies.
• Supported by multi-stakeholder funding.

Target Group

1. Patients: Adults/children with chronic or rare respiratory conditions NCDs, CRCs, Rare Disease, Long COVID and comorbidities.
2. Caregivers: Family members, caregivers and informal supporters.
3. Healthcare practitioners: Pulmonologists, physiotherapists, primary-care, clinical centers, healthcare systems (primary-care, clinics, hospitals, pharmacies, rehab centers, online providers requiring specialist respiratory care services).
4. Researchers in respiratory and digital healthcare.

Pre-Requisites and Requirements

Technical Requirements:

• Smartphone or table (iOS / Android) for patients and/or caregivers. (Provided by the user).
• Stable internet connection for app syncing, video coaching and data transmission (Provided by the user).
• Compatible devices: Bluetooth-enabled spirometers and wearables (e.g. Fitbit) (Provided by the user in the current phase).
• Healthcare IT infrastructure: Hospital must support HL7/FHIR standards for EHR integration (currently in pilot).

Organizational Requirements:

• Trained respiratory physiotherapists or clinicians to deliver tele-coaching.
• Data governance policies aligned with GDPR/CCPA and MDR.
• Institutional ethics approval for clinical use or research participation.
• Collaboration agreements with health systems, pharmacies or rehab centers for deployment.

Patient Readiness:

• Basic digital literacy to navigate the app.
• Willingness to engage in self-management and community activities.
• Interesting in participation in research.

Added Value

Clinical area

Impact

• Increased adherence to healthy habits in patients with COPD, post pulmonary rehabilitation program.(1)
• Increased adherence from 14-59% care and treatment adherence (2023 Colombia COPD cohort).
• Improvement in PEF in children and teeneagers with asthma (2021-2024 Inspiring Kids. Hospital Vall d’Hebron, Hospital Sant Pau, Hospital del Mar, Hospital Parc Taulí, Barcelona. Spain). (2)
• Improvement in QoL of patients with Bronchiectasis: Increased physical activity and significant reduction in symptoms assessed by St George Questionarie.(3)
• Improvement in inhaler adherence, dyspnoea management and QoL in patients with Cystic Fibrosis (2024, HUB Mexico).
• 575 Check@ir lung health online assessments (August 2025 ongoing campaign Global Respiratory Map).

User-centric

• Multi-language support (Spanish, English, Portuguese).

Innovation

• Awarded 1st International Congress on Rare Respiratory Diseases: Best Poster.
• Nominee Best Innovation Initiative, 2021 Barcelona Health HUB.
• Awarded SEPAR Gold Communication 2023.
• Finalist OaT adherence awards 2023, 2024 and 2025.
• Voted in 5 TOP Candidates New Medical Economics Frugal (2025).

Technical Specifications

• Platforms: iOS/Android apps + web portal + additional CRM resources (teams…).
• ISO 27001 certification is under way. This indicates that the platform is aligning with the global standard for Information Security Management Systems (ISMS), ensuring robust protection of patient data.
• Already compliant with GDPR (EU General Data Protection Regulation); CCPA (California Consumer Privacy Act); MDR (EU Medical Device Regulation for data governance.
• Data architecture is designed to be secure, privacy-first and audit-ready.
• Additionally, the platform follow HL7/FHIR standards for interoperability, supporting seamless integration with hospital EHRs. It has a GDPR-compliant data architecture, reinforcing its alignment with international privacy norms.
• Connectivity: M Devide e.g. bluetooth spirometers, wearables, IoT and air quality monitoring systems.

Business model

Non-profit foundation with multi-stakeholder funding prospected from:

• Grants.
• Pharma partnerships; Chiesi, AstraZeneca, GSK, Sanogi, MSD, Vertex, Boehringer-Ingelheim, Novartis…
• Tech: PARI, NDD…
• Private Donations.
• Services-subscriptions.

Freemium patient access: Basic features free, premium coaching for LMICs by stakeholder partners, donnors and subscriptions.

Maturity

• Market-ready: Active since 2015, 10k + patient.
• Scaled: Deployed in 8 countries (Spain, Mexico, Colombia, Argentina…).
• Evidence-bases: 12+peer-reviewed publications (e.g. JMIR 2020 RCT, HealthManagement, Archivos de bronconeumología…).

Regulatory Aspects

• Ethics approval for all clinical studies.
• MDR-data governance framework.
• HappyAir is available under agreement, to diverse stakeholders according to their profile, objectives and funding capacity- Services are free, suscription models or project-based depending on the scope and nature of the same. All services or integrations (e.g. Research collaborations, device testing or institutinal use) requiere contractual partnership agreements, data-sharing protocols, usage, always in compliance with GDPR and authenticated third party engagement and objectives. We have advisors and experts in all fields of interest including AI.

Practice Support and Access to demo

• Training resources are available for medical team: e-learning and online support.
• Lovexair provides technical support.
• Access to a demo: NDA is required.

REFERENCES

1. B. Jiménez-Reguera et al., “Development and Preliminary Evaluation of the Effects of an mHelath Web-Bases Platform (HappyAir) on Adherence to a Maintenance Program After Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease: Randomized Controlled Trial” JMIR mHealth and uHealth, vol. 8, no. 7. p. e18465, Jul 2020, doi: https://doi.org/10.2196/18465.
2. E. Maroto et al., “Efficacy of a digitally supported intervention for children and adolescents with difficult-to-control asthma (INSPIRINGKIDS): results from a multicentre randomized controlled trial” Archivos de Bronconeumología, Apr 2025, doi: https://doir.org/10.1016/j.arbres.2025.04.004.
3. E. Maroto et al., “Apoyo de la telefisioterapia al seguimiento de los pacientes con bronquiectasias: Papel de la herramienta digital HappyAir en el Proyecto Broncair”. Open Respiratory Archives 7 (2025) S1-S642. Page 311.
4. Projects report: https://bit.ly/MemoriaLovexair.